OHM PHARMA LAB. (PARADIGM) - LEFLOX TAB.

LEFLOX 250/500 (Levofloxacin) is a synthetic, broad spectrum, 3rd generation antibacterial agent. Chemically, Levofloxacin is a chiral fluorinated carboxy-quinolone.

Mechanism of Action

Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.